Biophysics of Transcription Initiation

We strive to understand the physical mechanisms of transcription initiation and other important DNA-protein interactions. More specifically, we use a variety of single-molecule and bulk biophysical techniques including both optical and magnetic tweezers and fluorescent microscopy to investigate how the assembly of initiation complexes on DNA promoters lead to transcription of genes. Our work is currently focused on the mechanisms of basal transcription initiation in Eukaryotes and on factor-regulated transcription in Mycobacterium tuberculosis.

Postdoctoral Position Available!
A postdoctoral position is available for those interested in mechanisms of transcription initiation in Eukaryotes. The ideal candidate will have previous experience with single-molecule techniques including optical tweezers, magnetic tweezers, and/or single-molecule fluorescence. Send CV, a summary of your scientific interests and accomplishments, and three references to egalburt AT washu DOT edu.

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Mechanisms of the eukaryotic pre-initiation complex

Unique and essential transcription factors in Mycobacterium tuberculosis