Biophysics of Transcription Initiation

We strive to understand the physical mechanisms of transcription initiation and other important DNA-protein interactions. More specifically, we use a variety of single-molecule and bulk biophysical techniques including both optical and magnetic tweezers and fluorescent microscopy to investigate how the assembly of initiation complexes on DNA promoters lead to transcription of genes. Our work is currently focused on the mechanisms of basal transcription initiation in Eukaryotes and on factor-regulated transcription in Mycobacterium tuberculosis.

Recent Lab News:

Click here to see all News

Mechanisms of the eukaryotic pre-initiation complex

Unique and essential transcription factors in Mycobacterium tuberculosis